Percy D H, Williams K L
Department of Pathology, Ontario Veterinary College, University of Guelph.
Lab Anim Sci. 1990 Nov;40(6):603-7.
Specific Pathogen Free (SPF) male Wistar rats were inoculated intranasally with Parker's rat coronavirus (PRC), then killed at various intervals post-inoculation (pi). PRC inoculated rats had transient respiratory signs. Intermandibular swelling was evident in some rats at 6-8 days pi. During the acute stages of the disease, inflammatory lesions were present in the respiratory tract and in the salivary and lacrimal glands. Regenerative lesions were observed in the salivary and lacrimal glands at 2 weeks pi. Inoculated rats seroconverted at 8-14 days pi, and significant coronaviral antibody titers were present in inoculated rats examined at 21 days pi with PRC. Changes in the respiratory tract and salivary and lacrimal glands were identical in incidence, distribution and nature to those observed in sialodacryoadenitis (SDA) virus inoculated Wistar rats. Thus, in the absence of viral isolation and characterization, "rat coronavirus infection" is a more appropriate term than either PRC infection or sialodacryoadenitis (SDA).
将无特定病原体（SPF）的雄性Wistar大鼠经鼻接种帕克大鼠冠状病毒（PRC），然后在接种后（pi）的不同时间点处死。接种PRC的大鼠出现短暂的呼吸道症状。在接种后6 - 8天，一些大鼠出现明显的下颌肿胀。在疾病的急性期，呼吸道以及唾液腺和泪腺出现炎症病变。在接种后2周，在唾液腺和泪腺观察到再生性病变。接种大鼠在接种后8 - 14天血清转化，在接种PRC后21天检测的接种大鼠中存在显著的冠状病毒抗体滴度。呼吸道以及唾液腺和泪腺的变化在发生率、分布和性质上与接种涎泪腺炎（SDA）病毒的Wistar大鼠中观察到的变化相同。因此，在没有病毒分离和鉴定的情况下，“大鼠冠状病毒感染”比PRC感染或涎泪腺炎（SDA）更合适。
