无细胞毒素梭状芽胞杆菌：与胆管炎相关的菌血症病例的临床和微生物学特征。
Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia.
机构信息
The Department of Internal Medicine, University of Michigan Health System, Ann Arbor, 48109, USA.
出版信息
Anaerobe. 2011 Oct;17(5):252-6. doi: 10.1016/j.anaerobe.2011.06.009. Epub 2011 Jun 25.
Abstract
Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.
摘要
产毒梭状芽孢杆菌菌株越来越多地被认为会导致人类发生具有中毒性休克综合征（TSS）特征的高度致命感染。两种糖基化毒素，致死毒素（TcsL）和出血毒素（TcsH）被认为在 TSS 的发病机制中很重要。虽然非产毒梭状芽孢杆菌菌株在体外表现出降低的细胞毒性和在感染的动物模型中降低的毒力，但关于它们在人类中的行为的数据很少。在这里，我们报告了在多微生物细菌性胆管炎背景下的非 TSS 产毒梭状芽孢杆菌感染。与这种感染相关的产毒梭状芽孢杆菌菌株既不携带编码 TcsL 的 tcsL 基因，也不携带编码 TcsH 的 tcsH 基因。此外，该菌株在体外既没有细胞毒性，也没有在小鼠败血性休克模型中致死。这些结果提供了额外的相关证据，表明 TcsL 和 TcsH 增加了 C. sordellii 感染期间的死亡率风险。
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