University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, United Kingdom.
Int J Cardiol. 2012 Jun 14;157(3):318-23. doi: 10.1016/j.ijcard.2011.06.088. Epub 2011 Jul 2.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, which is associated with substantial risk of stroke and thromboembolism. The epidemiology and health care burden associated with AF have increased significantly, and will continue to rise. Until recently, the concept and/or quantification of disease burden in AF tended to be ignored nor its consequences recognised. However, AF burden can now be assessed more accurately and reliably with the aid of cardiac rhythm management devices. There is a lot of interest on the issue of 'how much AF is needed to cause thromboembolism?' and this article summarises the available literature on this topic, with the aim of providing a better understanding of the clinical importance of device-detected atrial high-rate episodes and an overview of arrhythmia burden on thrombogenesis and clinical thromboembolism.
心房颤动（AF）是最常见的心律失常，与中风和血栓栓塞的风险显著相关。与 AF 相关的流行病学和医疗负担显著增加，且将持续上升。直到最近，AF 相关疾病负担的概念和/或量化问题往往被忽视，其后果也未得到认识。然而，借助心脏节律管理设备，现在可以更准确和可靠地评估 AF 负担。人们对“需要多少 AF 才能导致血栓栓塞？”这一问题非常关注，本文总结了这一主题的现有文献，旨在更好地理解设备检测到的心房高心率事件的临床重要性，并概述心律失常负担对血栓形成和临床血栓栓塞的影响。
