Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
Leukemia. 2011 Nov;25(11):1674-86. doi: 10.1038/leu.2011.167. Epub 2011 Jul 5.
Mobilizing bone cells to the head, astutely referred to as 'bonehead' therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke.
将骨细胞动员到头部,巧妙地称为“骨脑”治疗方法,是再生医学的一个主要学科。过去十年的研究证据越来越多,支持骨髓(BM)衍生细胞从 BM 迁移到外周血(PB)的能力,最终找到通往受伤大脑的途径。这种归巢作用在缺血性脑损伤后的 BM 干细胞动员中得到了例证。在这里,我回顾了越来越多的实验室研究,这些研究表明,移植的 BM 干细胞的治疗性动员在中风中的大脑可塑性和重塑中起作用。