Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, 18100 Granada, Spain.
Biomed Res Int. 2013;2013:312656. doi: 10.1155/2013/312656. Epub 2013 Jun 17.
Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. This paper reviews the regulation mechanisms underlying the homing and mobilization of BM hematopoietic stem/progenitor cells, investigating the following issues: (a) the role of different factors, such as stromal cell derived factor-1 (SDF-1), granulocyte colony-stimulating factor (G-CSF), and vascular cell adhesion molecule-1 (VCAM-1), among other ligands; (b) the stem cell count in peripheral blood and BM and influential factors; (c) the therapeutic utilization of this phenomenon in lesions in different tissues, examining the agents involved in HSPCs mobilization, such as the different forms of G-CSF, plerixafor, and natalizumab; and (d) the effects of this mobilization on BM-derived stem/progenitor cells in clinical trials of patients with different diseases.
造血干细胞（HSCs）从骨髓（BM）中释放、迁移和归巢的调控以及动员途径涉及到黏附分子、细胞因子、蛋白水解酶、基质细胞和造血细胞之间的复杂相互作用。鉴定新的调节造血干/祖细胞（HSPCs）细胞迁移的机制不仅对造血移植具有重要意义，而且对急性心肌梗死、脊髓损伤和中风等患者的再生医学中的细胞治疗也具有重要意义。本文综述了 BM 造血干/祖细胞归巢和动员的调控机制，研究了以下问题：（a）不同因子（如基质细胞衍生因子-1（SDF-1）、粒细胞集落刺激因子（G-CSF）和血管细胞黏附分子-1（VCAM-1）等配体）的作用；（b）外周血和 BM 中干细胞计数和影响因素；（c）该现象在不同组织损伤中的治疗利用，研究了与 HSPCs 动员相关的药物，如不同形式的 G-CSF、plerixafor 和 natalizumab；以及（d）这种动员对不同疾病患者临床试验中 BM 来源的干细胞/祖细胞的影响。
