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多功能中枢模式发生器中爆发性多节律的序参量。

Order parameter for bursting polyrhythms in multifunctional central pattern generators.

作者信息

Wojcik Jeremy, Clewley Robert, Shilnikov Andrey

机构信息

Neuroscience Institute and Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia 30303, USA.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 May;83(5 Pt 2):056209. doi: 10.1103/PhysRevE.83.056209. Epub 2011 May 16.

DOI:10.1103/PhysRevE.83.056209
PMID:21728632
Abstract

We examine multistability of several coexisting bursting patterns in a central pattern generator network composed of three Hodgkin-Huxley type cells coupled reciprocally by inhibitory synapses. We establish that the control of switching between bursting polyrhythms and their bifurcations are determined by the temporal characteristics, such as the duty cycle, of networked interneurons and the coupling strength asymmetry. A computationally effective approach to the reduction of dynamics of the nine-dimensional network to two-dimensional Poincaré return mappings for phase lags between the interneurons is presented.

摘要

我们研究了一个由三个霍奇金-赫胥黎型细胞通过抑制性突触相互耦合组成的中枢模式发生器网络中几种共存爆发模式的多重稳定性。我们确定,爆发性多节律之间的切换控制及其分岔由网络中间神经元的时间特征(如占空比)和耦合强度不对称性决定。本文提出了一种将九维网络动力学简化为中间神经元之间相位滞后的二维庞加莱返回映射的有效计算方法。

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