Ricalde A A, Hammer R P
Department of Anatomy, University of Hawaii School of Medicine, Honolulu 96822.
Neurosci Lett. 1990 Jul 31;115(2-3):137-43. doi: 10.1016/0304-3940(90)90444-e.
Basilar dendritic arborizations of layer II-III pyramidal neurons in primary somatosensory cortex of 5-day-old male rats were reconstructed following perinatal morphine, morphine/naltrexone, or saline vehicle administration. Morphine treatment was observed to reduce total dendritic length. This effect was limited to higher order dendritic branches, with terminal dendrites manifesting the greatest reduction of length. The action of morphine was presumably mediated by opiate receptors, since concurrent naltrexone administration completely reversed morphine effects on dendritic length and branching. These results suggest that opiates act during late ontogenesis to affect dendritic growth in cerebral cortex.
在新生雄性大鼠出生后的第5天，分别给予吗啡、吗啡/纳曲酮或生理盐水，之后重建初级体感皮层中II-III层锥体神经元的基底树突分支。观察到吗啡处理会减少树突总长度。这种效应仅限于高阶树突分支，其中终末树突的长度减少最为明显。吗啡的作用可能是由阿片受体介导的，因为同时给予纳曲酮可完全逆转吗啡对树突长度和分支的影响。这些结果表明，阿片类药物在个体发育后期发挥作用，影响大脑皮层的树突生长。
