Ketenci I, Unlü Y, Kaya H, Somdaş M A, Kontaş O, Oztürk M, Vural A
Department of Otorhinolaryngology, Erciyes University, Kayseri, Turkey.
J Laryngol Otol. 2011 Aug;125(8):e3. doi: 10.1017/S0022215111000843. Epub 2011 May 13.
Mucormycosis is an opportunist, often lethal fungal infection which occurs in immunocompromised patients. We present our experience in 14 patients with this condition.
A retrospective chart review was conducted for 14 patients treated for rhinocerebral mucormycosis.
Nine patients had diabetes mellitus and six had a haematological malignancy. Nine patients had cutaneous and/or palatal necrosis. Eleven patients were treated with amphotericin B and five with liposomal amphotericin B. Endoscopic sinus surgery was performed in five patients with disease limited to the sinonasal cavity; nine patients underwent more extensive surgery. Five patients with disease limited to the sinonasal cavity survived, while nine patients with widely disseminated disease died. Five of the nine diabetic patients died, as did five of the six patients with haematological malignancy.
Patients with rhinocerebral mucormycosis spreading outside the sinonasal cavity have a poor prognosis.
毛霉菌病是一种机会性感染，通常是致命的真菌感染，发生于免疫功能低下的患者。我们介绍我们治疗14例这种疾病患者的经验。
对14例接受鼻脑型毛霉菌病治疗的患者进行回顾性病历审查。
9例患者患有糖尿病，6例患有血液系统恶性肿瘤。9例患者有皮肤和/或腭部坏死。11例患者接受两性霉素B治疗，5例接受脂质体两性霉素B治疗。5例病变局限于鼻窦腔的患者接受了鼻内镜鼻窦手术；9例患者接受了更广泛的手术。5例病变局限于鼻窦腔的患者存活，而9例广泛播散性疾病患者死亡。9例糖尿病患者中有5例死亡，6例血液系统恶性肿瘤患者中也有5例死亡。
鼻脑型毛霉菌病扩散至鼻窦腔外的患者预后较差。
