Wyatt C L, Jensen L S, Rowland G N
Department of Poultry Science, University of Georgia, Athens 30602.
Poult Sci. 1990 Aug;69(8):1271-80. doi: 10.3382/ps.0691271.
Because previous studies indicated that cimetidine (CIMET) and isoniazid (ISON) may inhibit vitamin D metabolism in both rats and humans, experiments were conducted to evaluate the influence of these drugs on growth and bone development in male broiler chicks. Chicks were fed a corn and soybean meal basal diet containing various levels of the drugs for 21 days. Body weight gain (BWG), feed consumption per bird (FB), tibia ash (TA), tibia breaking force (TBF), and plasma calcium levels were measured. In birds fed a diet supplemented with 1,100 ICU D3/kg, CIMET at up to 300 ppm resulted in a significant linear decrease in TA as the drug level increased. Birds fed ISON up to 405 ppm had inconsistent responses in TA and TBF. Body weight gain was only depressed with the highest level of ISON (405 ppm). The effects of feeding 0, 150, or 300 ppm CIMET were also investigated when chicks were fed 200 or 1,000 ICU per kg vitamin D3. The interaction between vitamin D3 and CIMET was significant for BWG, FCB, TA, and TBF. These were significantly reduced as the CIMET level increased for birds fed the low vitamin D3 diet but were not significantly affected when fed the high D3 diet. In another study in which chicks were fed a diet with 1,100 ICU vitamin D3, lowering the dietary Ca, or P, or both did not result in any effect of CIMET on the chicks. The results indicate that CIMET possibly interferes with normal bone formation in chicks by altering vitamin D3 metabolism.
由于先前的研究表明西咪替丁（CIMET）和异烟肼（ISON）可能会抑制大鼠和人类体内的维生素D代谢，因此开展了实验以评估这些药物对雄性肉鸡生长和骨骼发育的影响。给雏鸡饲喂含有不同水平药物的玉米和豆粕基础日粮21天。测量了体重增加（BWG）、每只鸡的采食量（FB）、胫骨灰分（TA）、胫骨断裂力（TBF）和血浆钙水平。在饲喂添加1,100国际单位维生素D3/kg日粮的鸡中，随着药物水平的增加，高达300 ppm的西咪替丁导致胫骨灰分显著线性下降。饲喂高达405 ppm异烟肼的鸡在胫骨灰分和胫骨断裂力方面的反应不一致。仅在最高水平的异烟肼（405 ppm）时体重增加受到抑制。当雏鸡饲喂每千克200或1,000国际单位维生素D3时，还研究了饲喂0、150或300 ppm西咪替丁的效果。维生素D3和西咪替丁之间的相互作用对体重增加、采食量、胫骨灰分和胫骨断裂力有显著影响。对于饲喂低维生素D3日粮的鸡，随着西咪替丁水平的增加，这些指标显著降低，但饲喂高维生素D3日粮时则没有显著影响。在另一项研究中，给雏鸡饲喂含有1,100国际单位维生素D3的日粮，降低日粮中的钙、磷或两者都降低，西咪替丁对雏鸡没有任何影响。结果表明，西咪替丁可能通过改变维生素D3代谢来干扰雏鸡的正常骨骼形成。
