Cai Xue-Jiao, Hong Jun-Yin, Chen Yi, Yu Kang
Department of Blood Transfusion, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):801-4.
This study was purposed to investigate the effect of ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT) on erythroid lineage hematopoiesis. The changes of ABO group, IgM and IgG antibody in 16 patients received ABO-incompatible allo-HSCT were detected. The results showed that ABO-incompatible allo-HSCT were successfully engrafted in 16 patients, and there was no difference in reconstitution of platelets and neutrophils between ABO-incompatible and ABO-compatible transplantation (p > 0.05). The time of erythroid lineage reconstitution was prolonged (p < 0.05), the disappearance time of isoagglutinins against donor-type RBC in major and bidirectional ABO-incompatible recipients was correlated with the time of erythroid lineage reconstitution. It is concluded that ABO-incompatible allo-HSCT may lead to prolong recovery of erythroid lineage hematopoiesis. Before transplantation, the removal of anti-donor isoagglutinins by plasmapheresis or transfusion of donor's erythrocytes for neutralizing the isoagglutinins against donor's erythrocytes in the recipients may facilitate RBC engraftment and reduce erythrocyte transfusion.
本研究旨在探讨ABO血型不合的异基因造血干细胞移植（allo-HSCT）对红系造血的影响。检测了16例接受ABO血型不合allo-HSCT患者的ABO血型、IgM和IgG抗体变化。结果显示，16例患者ABO血型不合allo-HSCT均成功植入，ABO血型不合与血型相合移植之间血小板和中性粒细胞的重建无差异（p>0.05）。红系重建时间延长（p<0.05），主要和双向ABO血型不合受者中针对供者型红细胞的同种凝集素消失时间与红系重建时间相关。结论是，ABO血型不合allo-HSCT可能导致红系造血恢复延长。移植前，通过血浆置换去除抗供者同种凝集素或输注供者红细胞以中和受者体内针对供者红细胞的同种凝集素，可能有助于红细胞植入并减少红细胞输注。
