Meunier F
Service de Médecine interne, Université Libre de Bruxelles, Institut Jules Bordet.
Recenti Prog Med. 1990 Jan;81(1):18-22.
Invasive fungal infections are common in immunocompromised patients. Early diagnosis is still difficult and prophylactic modalities seems mandatory but are yet to be defined. Standard therapy of invasive fungal infections relies on the administration of intravenous amphotericin B. This agent is difficult to administer and toxic. Recently, new antifungal agents have been developed and are currently under investigation. Those new agents included itraconazole and fluconazole as well as new galenic preparations of amphotericin B such as liposomes. All these studies should provide optimal management of invasive fungal infections and improve the prognosis of those patients.
侵袭性真菌感染在免疫功能低下的患者中很常见。早期诊断仍然困难，预防性治疗似乎是必要的，但尚未明确。侵袭性真菌感染的标准治疗依赖于静脉注射两性霉素B。这种药物难以给药且有毒性。最近，新的抗真菌药物已经研发出来，目前正在进行研究。这些新药物包括伊曲康唑和氟康唑，以及两性霉素B的新剂型，如脂质体。所有这些研究都应能为侵袭性真菌感染提供最佳治疗，并改善这些患者的预后。
