[脑钠钾ATP酶催化亚基α⁺同工型的热稳定性]
[Thermolability of alpha+-isoform of the catalytic subunit of brain Na+,K+-ATPase].
作者信息
Kaplia A A, Kravtsov A V
出版信息
Ukr Biokhim Zh (1978). 1990 Jul-Aug;62(4):39-44.
PMID:2173186
Abstract
Thermal stabilities of Na+,K(+)-ATPase isozymes from the rat brain and kidney tissues are compared. It is established that heat treatment of Na+,K(+)-ATPase preparations from the brain decreases the high affinity component of the ouabain inhibition of the enzyme activity due to selective inactivation of alpha-isoform. Its higher thermal lability in comparison with alpha-isoform is confirmed.
摘要
比较了大鼠脑和肾组织中Na +，K（+）-ATP酶同工酶的热稳定性。已确定，对来自大脑的Na +，K（+）-ATP酶制剂进行热处理会降低哇巴因对酶活性抑制的高亲和力成分，这是由于α同工型的选择性失活所致。证实了其与α同工型相比具有更高的热不稳定性。
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