Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC.
Macromol Rapid Commun. 2011 Sep 15;32(18):1442-6. doi: 10.1002/marc.201100157. Epub 2011 Jul 5.
This paper develops a non-spherical polymeric micelle using an amphiphilic block copolymer and a porphyrin crystalline structure. The nanoscale polymer micelles were characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM), revealing particle sizes of approximately 150 nm with a particular shape in the hexagonal lattice. The shape shows the selective uptake efficacy for the HeLa and macrophage cells, and inhibits phagocytosis against the macrophage.
本文使用两亲嵌段共聚物和卟啉晶体结构开发了一种非球形聚合物胶束。通过透射电子显微镜(TEM)和原子力显微镜(AFM)对纳米级聚合物胶束进行了表征,发现颗粒尺寸约为 150nm,具有六边形晶格中的特殊形状。这种形状显示了对 HeLa 和巨噬细胞的选择性摄取效果,并抑制了巨噬细胞的吞噬作用。