Department of Anthropology, University of Oregon, Eugene, Oregon 97403, USA.
Am J Hum Biol. 2011 Sep-Oct;23(5):703-9. doi: 10.1002/ajhb.21200. Epub 2011 Jul 5.
Alterations in thyroid function appear to play a central role in adaptation to Arctic environments. Increased thyroid activity in indigenous circumpolar populations is associated with upregulated metabolism, including elevated basal metabolic rate (BMR); however, little is known about the possible health consequences of these climate-induced changes on thyroid function. The focus of the present study is to determine the prevalence of autoimmune thyroid disorders and their lifestyle and metabolic correlates among a sample of indigenous Yakut adults from northeastern Siberia.
Anthropometric dimensions, health data, and plasma samples were collected among 281 adults (143 women, 138 men; ≥18 years old) from the rural community of Berdygestiakh (62°N, 127°E; pop. 4,900), Sakha Republic (Yakutia), Russia. BMR measurements were available for 96 women and 98 men. Free triiodothyronine (T(3) ), free thyroxine (T(4) ), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibody (TPOAb) levels were determined using enzyme immunoassay.
Twenty-two percent of women and 6% of men had clinically elevated (>30 IU/ml) TPOAb. TPOAb was positively correlated with TSH (P < 0.01), T(3) (P < 0.05), and T(4) (P < 0.05) in women and showed a positive trend with T(4) (P = 0.06) in men. Monthly household income was significantly positively correlated with TPOAb in men (P < 0.01) and showed a trend among women (P = 0.06).
Although preliminary, these findings document higher than expected TPOAb levels among Yakut women and suggest possible consequences of increased thyroid activity associated with circumpolar adaptation and social change.
甲状腺功能的改变似乎在适应北极环境中起着核心作用。在土著环极人群中，甲状腺活性的增加与代谢上调有关，包括基础代谢率（BMR）升高；然而，对于这些由气候引起的甲状腺功能变化对健康可能产生的影响，人们知之甚少。本研究的重点是确定在来自俄罗斯萨哈共和国（雅库特）东北部农村社区 Berdygestiakh 的一群土著雅库特成年人中，自身免疫性甲状腺疾病及其生活方式和代谢相关性的患病率。
在 Berdygestiakh（62°N，127°E；人口 4900）农村社区，收集了 281 名成年人（143 名女性，138 名男性；≥18 岁）的人体测量学维度、健康数据和血浆样本。96 名女性和 98 名男性的基础代谢率测量值可用。使用酶免疫测定法测定游离三碘甲状腺原氨酸（T(3)）、游离甲状腺素（T(4)）、促甲状腺激素（TSH）和抗甲状腺过氧化物酶抗体（TPOAb）水平。
22%的女性和 6%的男性 TPOAb 临床升高（>30 IU/ml）。TPOAb 与 TSH（P < 0.01）、T(3)（P < 0.05）和 T(4)（P < 0.05）在女性中呈正相关，并在男性中与 T(4)呈正相关趋势（P = 0.06）。男性月家庭收入与 TPOAb 呈显著正相关（P < 0.01），女性呈正相关趋势（P = 0.06）。
尽管初步的，这些发现记录了雅库特女性中高于预期的 TPOAb 水平，并表明与环极适应和社会变化相关的甲状腺活性增加可能产生的后果。
