Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University Feinburg School of Medicine, 303 E. Superior Street, Chicago, IL 60611, USA.
J Womens Health (Larchmt). 2011 Aug;20(8):1239-43. doi: 10.1089/jwh.2010.2648. Epub 2011 Jul 6.
Approximately 10%-15% of clinically recognized pregnancies end with a first trimester loss. Cytogenetic analysis of products of conception (POC) has revealed that a large proportion of these spontaneous miscarriages are a result of chromosomal abnormalities. However, relatively few studies have evaluated chromosomal abnormalities in pregnancies achieved using assisted reproductive technologies (ART). Here, we review the incidence and type of chromosomal abnormalities that occurred in our infertility patient population undergoing ART and provide a review of the literature pertaining to this subject.
A retrospective chart review of all patients from our medical center who conceived using ART between January 2000 and January 2008, who experienced a subsequent early pregnancy loss, and whose POCs were successfully karyotyped were included. We also conducted a literature review in PubMed, searching for other articles on this subject.
Two hundred fourteen patients conceived with ART, experienced an early loss, and subsequently underwent a dilation and curettage (D&C) between 2000 and 2008. A total of 59 (27%) patients chose to have cytogenetic testing, and their POCs were successfully karyotyped. The overall rate of aneuploidy in this group was 83%. Our PubMed search revealed a total of 12 studies that were identified and evaluated and deemed appropriate for review.
Consistent with most of the literature, we found a high rate of aneuploidy present in infertile patients conceiving using ART. Because an abnormal karyotype provides an explanation for an early loss, this and other studies seem to suggest that routinely carrying out this assessment in such patients may be of value.
约 10%-15%的临床确诊妊娠以孕早期流产而告终。对妊娠产物（POC）的细胞遗传学分析显示，这些自然流产中有很大一部分是由于染色体异常所致。然而，只有少数研究评估了辅助生殖技术（ART）妊娠中的染色体异常。在此，我们回顾了在接受 ART 的不孕患者人群中发生的染色体异常的发生率和类型，并对该主题的文献进行了综述。
对 2000 年 1 月至 2008 年 1 月期间在我们医疗中心接受 ART 并随后经历早期妊娠丢失且 POC 成功核型分析的所有患者进行回顾性图表审查。我们还在 PubMed 上进行了文献综述，搜索了关于该主题的其他文章。
在 2000 年至 2008 年间，共有 214 名患者接受 ART 受孕，经历了早期流产，并随后进行了扩张和刮宫术（D&C）。共有 59 名（27%）患者选择进行细胞遗传学检测，其 POC 成功进行了核型分析。该组的非整倍体率总体为 83%。我们在 PubMed 上的搜索共发现了 12 项研究，这些研究被确定并进行了评估，认为适合进行综述。
与大多数文献一致，我们发现接受 ART 受孕的不孕患者中存在很高的非整倍体率。由于异常核型为早期流产提供了一个解释，因此这项和其他研究似乎表明，在这些患者中常规进行这种评估可能具有价值。
