Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Fertil Steril. 2011 Feb;95(2):503-6. doi: 10.1016/j.fertnstert.2010.09.019. Epub 2010 Oct 14.
To determine if pregnancies conceived through infertility treatment are at increased risk of cytogenetic abnormalities in the late first trimester compared with spontaneously conceived pregnancies, or if there is increased risk when comparing less invasive infertility treatment (in vivo group) to in vitro fertilization (in vitro group).
Retrospective case-controlled study.
University hospital.
PATIENT(S): A total of 1,606 women who spontaneously conceived and 559 women who conceived through infertility treatment undergoing chorionic villus sampling (CVS).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Cytogenetic abnormalities diagnosed by CVS.
RESULT(S): No difference in cytogenetic abnormalities was found when comparing spontaneously conceived pregnancies to those conceived through infertility treatment (7.0% versus 5.4%). We also found no difference in the prevalence of cytogenetic abnormalities when comparing in vivo and in vitro fertilization subgroups (4.7% versus 5.8%). Finally, no difference was found when comparing the prevalence of different types of cytogenetic abnormalities between groups.
CONCLUSION(S): Infertility treatment does not increase the risk of carrying a cytogenetically abnormal fetus in the late first trimester, nor does it increase the preponderance for any specific type of abnormality.
与自然受孕妊娠相比，确定通过不孕治疗受孕的妊娠在孕早期末是否具有更高的细胞遗传学异常风险，或者与比较微创的不孕治疗（体内组）与体外受精（体外组）相比，是否存在更高的风险。
回顾性病例对照研究。
大学医院。
共 1606 名自然受孕的妇女和 559 名通过不孕治疗接受绒毛膜绒毛取样（CVS）的妇女。
无。
CVS 诊断的细胞遗传学异常。
与自然受孕妊娠相比，不孕治疗妊娠的细胞遗传学异常无差异（7.0%对 5.4%）。我们还发现，体内和体外受精亚组的细胞遗传学异常发生率也没有差异（4.7%对 5.8%）。最后，各组之间不同类型细胞遗传学异常的发生率也没有差异。
不孕治疗不会增加孕早期末携带细胞遗传学异常胎儿的风险，也不会增加任何特定类型异常的优势。
