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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Trush M A, Twerdok L E, Esterline R L

Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.

Xenobiotica. 1990 Sep;20(9):925-32. doi: 10.3109/00498259009046908.

Polymorphonuclear leucocytes (PMNs) from human, mouse and rat were compared for their ability to activate benzo(a)pyrene-7,8-diol to a DNA-binding intermediate and a chemiluminescent dioxetane derivative. 2. Human PMNs activated benzo(a)pyrene-7,8-diol to the greatest extent, which correlated with their rate of superoxide anion generation and myeloperoxidase activity relative to these activities by PMNs from mice and rats. 3. Benzo(a)pyrene-7,8-diol chemiluminescence elicited by PMNs from all three species was significantly inhibited by azide, a myeloperoxidase inhibitor. On the other hand, superoxide dismutase (SOD) was very effective in inhibiting benzo(a)pyrene-7,8-diol chemiluminescence with mouse PMNs but not human or rat PMNs. Mouse PMNs exhibited a high rate of superoxide generation but low myeloperoxidase activity, whereas rat PMNs exhibited a low rate of superoxide generation but high myeloperoxidase activity.

对来自人、小鼠和大鼠的多形核白细胞（PMNs）激活苯并(a)芘-7,8-二醇生成一种与DNA结合的中间体和一种化学发光二氧杂环丁烷衍生物的能力进行了比较。2. 人PMNs激活苯并(a)芘-7,8-二醇的程度最大，这与其超氧阴离子生成速率以及相对于小鼠和大鼠PMNs的这些活性的髓过氧化物酶活性相关。3. 来自所有三个物种的PMNs引发的苯并(a)芘-7,8-二醇化学发光被叠氮化物（一种髓过氧化物酶抑制剂）显著抑制。另一方面，超氧化物歧化酶（SOD）对抑制小鼠PMNs的苯并(a)芘-7,8-二醇化学发光非常有效，但对人或大鼠PMNs无效。小鼠PMNs表现出高的超氧生成速率但低的髓过氧化物酶活性，而大鼠PMNs表现出低的超氧生成速率但高的髓过氧化物酶活性。

Trush M A, Twerdok L E, Esterline R L

Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.

Xenobiotica. 1990 Sep;20(9):925-32. doi: 10.3109/00498259009046908.

Polymorphonuclear leucocytes (PMNs) from human, mouse and rat were compared for their ability to activate benzo(a)pyrene-7,8-diol to a DNA-binding intermediate and a chemiluminescent dioxetane derivative. 2. Human PMNs activated benzo(a)pyrene-7,8-diol to the greatest extent, which correlated with their rate of superoxide anion generation and myeloperoxidase activity relative to these activities by PMNs from mice and rats. 3. Benzo(a)pyrene-7,8-diol chemiluminescence elicited by PMNs from all three species was significantly inhibited by azide, a myeloperoxidase inhibitor. On the other hand, superoxide dismutase (SOD) was very effective in inhibiting benzo(a)pyrene-7,8-diol chemiluminescence with mouse PMNs but not human or rat PMNs. Mouse PMNs exhibited a high rate of superoxide generation but low myeloperoxidase activity, whereas rat PMNs exhibited a low rate of superoxide generation but high myeloperoxidase activity.

对来自人、小鼠和大鼠的多形核白细胞（PMNs）激活苯并(a)芘-7,8-二醇生成一种与DNA结合的中间体和一种化学发光二氧杂环丁烷衍生物的能力进行了比较。2. 人PMNs激活苯并(a)芘-7,8-二醇的程度最大，这与其超氧阴离子生成速率以及相对于小鼠和大鼠PMNs的这些活性的髓过氧化物酶活性相关。3. 来自所有三个物种的PMNs引发的苯并(a)芘-7,8-二醇化学发光被叠氮化物（一种髓过氧化物酶抑制剂）显著抑制。另一方面，超氧化物歧化酶（SOD）对抑制小鼠PMNs的苯并(a)芘-7,8-二醇化学发光非常有效，但对人或大鼠PMNs无效。小鼠PMNs表现出高的超氧生成速率但低的髓过氧化物酶活性，而大鼠PMNs表现出低的超氧生成速率但高的髓过氧化物酶活性。