Sauerbrei A, Wutzler P, Pfister W, Kaiser U, Schreiber D, Rüdiger K D
Institut für Medizinische Mikrobiologie, Medizinischen Akademie Erfurt.
Zentralbl Allg Pathol. 1990;136(5):419-25.
An attempt was made by means of microbiological and histomorphological methods for diagnostic elucidation of reactive lymphadenopathies in 52 patients. The serological findings differed from those recorded from clinically intact individuals, in that they included not only increased prevalence of antibodies but also increased antibody titres to cytomegalovirus, influenza virus, and toxoplasma gondii. The dynamic of antibody titres against antigens specific of herpesvirus, influenza virus, and toxoplasma gondii were followed up and enabled positive detection in 11 of 18 patients of active infections with the above pathogens involved. Histologically, the lymph nodes affected were characterised by alterations reminiscent to Piringer lymphadenitis. While, in the course of bacteriological investigations, various bacterial species were isolated from lymph node tissue of 35 patients, direct morphological identification from lymph node sections failed to work. Immature sinus histiocytosis and an increase in phagocytosis activity were among the typical tissue findings.
通过微生物学和组织形态学方法对52例反应性淋巴结病患者进行诊断性阐明。血清学结果与临床正常个体的记录不同，不仅抗体患病率增加，而且针对巨细胞病毒、流感病毒和弓形虫的抗体滴度也增加。对针对疱疹病毒、流感病毒和弓形虫特异性抗原的抗体滴度动态进行了跟踪，在18例患者中有11例检测到上述病原体的活动性感染呈阳性。组织学上，受影响的淋巴结的特征是类似于皮林格淋巴结炎的改变。虽然在细菌学调查过程中，从35例患者的淋巴结组织中分离出了各种细菌种类，但从淋巴结切片进行直接形态学鉴定未能成功。未成熟的窦组织细胞增多和吞噬活性增加是典型的组织学表现。
