Auer Ulrike, Moens Yves
Department of Anaesthesiology and Perioperative Intensive Care, University of Veterinary Medicine Vienna, Vienna, Austria.
Vet Ophthalmol. 2011 Jul;14(4):244-7. doi: 10.1111/j.1463-5224.2010.00870.x. Epub 2011 Apr 18.
The production of a central eye to ease surgical access for intraocular surgery is generally dependent on the depth of anesthesia. The aim of this study was to evaluate the eyeball position under muscle relaxation with rocuronium during general anesthesia.
Twenty horses, body weight 480 ± 62 kg; age 12.6 ± 6.2 years (mean ± SD) were anesthetised for various ophthalmic surgeries. Horses were premedicated with acepromazine, xylazine, and butorphanol intravenously and anesthesia induced with ketamine and diazepam. Anesthesia was maintained with isoflurane in 100% oxygen and 0.6 mL/kg/h of an infusion containing midazolam, ketamine, and xylazine diluted in 500 mL 0.9% NaCl. Horses were mechanically ventilated. Neuromuscular function was assessed with an acceleromyograph (TOF-Guard®) and the N. peroneus superficialis was stimulated every 15 s with a train-of-four stimulation pattern. A dose of 0.3 mg/kg rocuronium was administered intravenously. The changes in the eyeball position were recorded.
The dose of 0.3 mg/kg rocuronium produced a 100% neuromuscular block in all horses. Onset time and clinical duration of block was 2.38 ± 2.02 min (range 0.5-8) and 32 ± 18.6 min (range 7.7-76.2), respectively. The globe rotated to central position within 31 ± 2.8 s. The whole iris was visible after 42 ± 7.7 s in all horses. No additional bolus of rocuronium was necessary for any surgery.
Neuromuscular blockade with rocuronium bromide can be used safely to facilitate ophthalmic surgery in equines.
为便于眼内手术而制造一个中央眼通常取决于麻醉深度。本研究的目的是评估全身麻醉期间使用罗库溴铵进行肌肉松弛时眼球的位置。
20匹马，体重480±62千克；年龄12.6±6.2岁（平均值±标准差），接受各种眼科手术麻醉。马静脉注射乙酰丙嗪、赛拉嗪和布托啡诺进行术前用药，并用氯胺酮和地西泮诱导麻醉。用异氟醚在100%氧气中维持麻醉，并以0.6毫升/千克/小时的速度输注含咪达唑仑、氯胺酮和赛拉嗪的混合液，该混合液用500毫升0.9%氯化钠稀释。马进行机械通气。用加速度肌动描记仪（TOF-Guard®）评估神经肌肉功能，每隔15秒用四个成串刺激模式刺激腓浅神经。静脉注射0.3毫克/千克的罗库溴铵。记录眼球位置的变化。
0.3毫克/千克的罗库溴铵剂量在所有马匹中产生了100%的神经肌肉阻滞。阻滞的起效时间和临床持续时间分别为2.38±2.02分钟（范围0.5 - 8分钟）和32±18.6分钟（范围7.7 - 76.2分钟）。眼球在31±2.8秒内旋转至中央位置。所有马匹在42±7.7秒后整个虹膜可见。任何手术都无需额外追加罗库溴铵。
溴化罗库溴铵神经肌肉阻滞可安全用于促进马的眼科手术。
