Department of Family Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
J Clin Psychiatry. 2011 Jun;72(6):e19. doi: 10.4088/JCP.10126tx1c.
Major depressive disorder is a highly prevalent, chronic, and disabling disease affecting millions of individuals worldwide. The burden of major depressive disorder includes impaired role functioning, decreased quality of life, the development of medical conditions, and increased morbidity and mortality. The long-term, recurrent nature of depression and its frequent resistance to available therapies lead to increased utilization of health services, which represents a large financial burden in health care costs. Major depressive disorder is often undertreated; however, even when treatment is adequate, remission rates are low and partial response is common.
重度抑郁症是一种在全球范围内影响数百万人的高发性、慢性和致残性疾病。重度抑郁症的负担包括角色功能受损、生活质量下降、引发医疗状况以及发病率和死亡率增加。抑郁的长期性、复发性及其对现有治疗方法的频繁抵抗导致卫生服务的利用增加，这在医疗保健成本方面构成了巨大的经济负担。重度抑郁症常常治疗不足；然而，即使治疗充分，缓解率也很低，部分反应很常见。
