1st Department of Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany.
Clin Appl Thromb Hemost. 2012 Jan-Feb;18(1):87-91. doi: 10.1177/1076029611412359. Epub 2011 Jul 6.
An upregulation of platelet CD40 ligand (CD40L) and CD62P has been described in atherosclerotic cardiovascular diseases and among patients with acute cerebral ischemia. Correlation between platelet and monocyte activation and the etiology of ischemic stroke were examined in 41 patients with acute ischemic stroke. Compared to 10 controls, all patients with stroke showed a significantly elevated platelet expression of CD40L (P < .001) and had significantly higher amounts of platelet-monocyte aggregates (P = .002). Plasma levels of interleukin 7 were significantly lower in patients with stroke compared to controls (P = .006). Patients with small artery disease had a significantly higher platelet CD40L expression than patients with cardioembolic stroke (P = .029). Plasma levels of soluble CD40L were significantly higher in patients with large artery disease compared to patients with cardioembolic stroke (P = .047). In conclusion, patients with acute ischemic stroke show an upregulation of platelet CD40L and an activation of cellular coagulation with highest activation in the large artery disease subgroup.
血小板 CD40 配体（CD40L）和 CD62P 的上调已在动脉粥样硬化性心血管疾病和急性脑缺血患者中描述。在 41 例急性缺血性脑卒中患者中，检查了血小板和单核细胞活化与缺血性脑卒中病因之间的相关性。与 10 名对照相比，所有卒中患者的血小板 CD40L 表达均显著升高（P <.001），血小板-单核细胞聚集体数量也显著升高（P =.002）。与对照组相比，卒中患者的血浆白细胞介素 7 水平明显降低（P =.006）。小动脉疾病患者的血小板 CD40L 表达明显高于心源性栓塞性卒中患者（P =.029）。大动脉疾病患者的血浆可溶性 CD40L 水平明显高于心源性栓塞性卒中患者（P =.047）。总之，急性缺血性脑卒中患者的血小板 CD40L 表达上调，细胞凝血活化，大动脉疾病亚组的活化程度最高。
