Cardiology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Angiology. 2012 May;63(4):241-4. doi: 10.1177/0003319711413892. Epub 2011 Jul 6.
The aim of this study is to determine mean platelet volume (MPV) in a population with non-ST-elevation acute coronary syndrome (nSTEACS) and explore its relation with prognosis. Patients (n = 329) with a diagnosis of nSTEACS at admission were recruited, with a determination of MPV in the first 12 hours at admission. We also collected blood from 87 healthy controls. A composite end point of cardiovascular death and new ACS was assessed at 6-month follow-up. Patients with nSTEACS showed larger platelets (MPV: 11.0 [10.3-11.8] vs 9.2 [8.6-10.0] fL; P < .001.). In Cox regression analysis, MPV at admission was a significant predictor of cardiovascular adverse events in univariate analysis, hazard ratio (HR) 1.4 95% confidence interval (CI) 1.1-1.8; P = .018; but after adjustment with clinical variables, MPV lost its statistical significance. In conclusion, patients with nSTEACS present with larger platelets than healthy controls, however this parameter did not show an independent prognostic significance at 6-month follow-up.
本研究旨在确定非 ST 段抬高型急性冠脉综合征（nSTEACS）患者的平均血小板体积（MPV），并探讨其与预后的关系。纳入了 nSTEACS 入院诊断的 329 例患者，在入院的头 12 小时内测定 MPV。我们还从 87 名健康对照者中采集了血液。在 6 个月的随访中评估心血管死亡和新发 ACS 的复合终点。nSTEACS 患者的血小板较大（MPV：11.0 [10.3-11.8] 比 9.2 [8.6-10.0] fL；P <.001）。在单因素 Cox 回归分析中，入院时的 MPV 是心血管不良事件的显著预测因子，危险比（HR）1.4，95%置信区间（CI）1.1-1.8；P =.018；但经过临床变量调整后，MPV 失去了统计学意义。总之，nSTEACS 患者的血小板大于健康对照组，但在 6 个月随访时，该参数并未显示出独立的预后意义。
