Spandidos D A, Zakinthinos S, Petraki C, Sotsiou F, Yiagnisis M, Dimopoulos A M, Roussos C, Field J K
Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
Anticancer Res. 1990 Sep-Oct;10(5A):1105-14.
Ras p21 and myc p62 expression has been examined immunohistochemically in seventy specimens of bronchial carcinomas. Both ras and myc oncoproteins were found to be overexpressed at a higher frequency in non small cell carcinomas (squamous cell carcinomas and adenocarcinomas) compared to the small cell carcinoma specimens; however only myc p62 overexpression was found to be statistically significant. Also, ras p21 oncoprotein expression was frequently overexpressed in adenocarcinomas compared to squamous cell carcinomas (p less than 0.05). Overexpression of c-myc p62 was found to correlate with poorly differentiated squamous cell carcinomas compared to the well and moderately differentiated tumors. The results of this study indicate that both the ras and myc oncogenes are important in the progression of bronchial carcinomas.
已采用免疫组织化学方法检测了70例支气管癌标本中的Ras p21和Myc p62表达。与小细胞癌标本相比，在非小细胞癌（鳞状细胞癌和腺癌）中，Ras和Myc癌蛋白均以更高的频率过表达；然而，仅Myc p62过表达具有统计学意义。此外，与鳞状细胞癌相比，腺癌中Ras p21癌蛋白表达经常过表达（P<0.05）。与高分化和中分化肿瘤相比，发现c-Myc p62过表达与低分化鳞状细胞癌相关。本研究结果表明，Ras和Myc癌基因在支气管癌进展中均很重要。
