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Fluorescence lifetime optical tomography in weakly scattering media in the presence of highly scattering inclusions.

作者信息

Soloviev Vadim Y, Arridge Simon R

机构信息

Department of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom.

出版信息

J Opt Soc Am A Opt Image Sci Vis. 2011 Jul 1;28(7):1513-23. doi: 10.1364/JOSAA.28.001513.

DOI:10.1364/JOSAA.28.001513
PMID:21734752
Abstract

We consider the problem of fluorescence lifetime optical tomographic imaging in a weakly scattering medium in the presence of highly scattering inclusions. We suggest an approximation to the radiative transfer equation, which results from the assumption that the transport coefficient of the scattering media differs by an order of magnitude for weakly and highly scattering regions. The image reconstruction algorithm is based on the variational framework and employs angularly selective intensity measurements. We present numerical simulation of light scattering in a weakly scattering medium that embeds highly scattering objects. Our reconstruction algorithm is verified by recovering optical and fluorescent parameters from numerically simulated datasets.

摘要

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