影响吞咽后食管下括约肌松弛的因素。
Factors influencing lower esophageal sphincter relaxation after deglutition.
机构信息
Department of Surgery, University of Linköping, SE-58185 Linköping, Sweden.
出版信息
World J Gastroenterol. 2011 Jun 21;17(23):2844-7. doi: 10.3748/wjg.v17.i23.2844.
AIM
To study the relationship between upper esophageal sphincter (UES) relaxation, peristaltic pressure and lower esophageal sphincter (LES) relaxation following deglutition in non-dysphagic subjects.
METHODS
Ten non-dysphagic adult subjects had a high-resolution manometry probe passed transnasally and positioned to cover the UES, the esophageal body and the LES. Ten water swallows in each subject were analyzed for time lag between UES relaxation and LES relaxation, LES pressure at time of UES relaxation, duration of LES relaxation, the distance between the transition level (TL) and the LES, time in seconds that the peristaltic wave was before (negative value) or after the TL when the LES became relaxed, and the maximal peristaltic pressure in the body of the esophagus.
RESULTS
Relaxation of the LES occurred on average 3.5 s after the bolus had passed the UES and in most cases when the peristaltic wave front had reached the TL. The LES remained relaxed until the peristaltic wave faded away above the LES.
CONCLUSION
LES relaxation seemed to be caused by the peristaltic wave pushing the bolus from behind against the LES gate.
目的
研究非吞咽困难受试者吞咽后食管上括约肌（UES）松弛、蠕动压力与食管下括约肌（LES）松弛之间的关系。
方法
10 名非吞咽困难的成年受试者经鼻插入高分辨率测压探头，以覆盖UES、食管体和 LES。对每位受试者的 10 次水吞咽进行分析，以研究 UES 松弛与 LES 松弛之间的时滞、UES 松弛时的 LES 压力、LES 松弛持续时间、过渡区（TL）与 LES 之间的距离、TL 松弛时食管体中蠕动波提前（负值）或滞后的时间以及食管体中的最大蠕动压力。
结果
UES 内的食团平均在 3.5 秒后通过UES 松弛，且大多数情况下，当蠕动波前到达 TL 时松弛。LES 保持松弛，直到蠕动波在 LES 上方消失。
结论
LES 松弛似乎是由蠕动波将食团从后方推向 LES 门引起的。
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