Lorenc Anna, Seremak-Mrozikiewicz Agnieszka, Drews Krzysztof, Ratajczak Paweł, Puszczewicz Mariusz
Klinika Perinatologii i Chorób Kobiecych Uniwersytet Medyczny w Poznaniu, Polska.
Ginekol Pol. 2011 Apr;82(4):297-303.
The antiphospholipid syndrome (APS) is a systemic non-inflammatory and autoimmune connective tissue disease. ASP is characterized by formation of autoantibodies against cell membrane phospholipids which act as procaogulation factors. Association with recurrent pregnancy loss, intrauterine growth retardation, preeclampsia and placenta ablation makes ASP a serious perinatologic problem. The primary form can evaluate into lupus-like disease or full-symptomatic lupus erythematosus, both usually preceded by acute form of APS. In pregnant women this situation may present considerable diagnostic problems. The aim of this work was to present a patient with acute primary antiphospholipid syndrome during pregnancy and puerperium, which subsequently was diagnosed as systemic lupus erythematosus flare. Such progression is rare and, despite several previous reports, requires extensive explanations and research.
抗磷脂综合征（APS）是一种全身性非炎症性自身免疫性结缔组织病。APS的特征是形成针对细胞膜磷脂的自身抗体，这些磷脂作为促凝因子起作用。与复发性流产、胎儿生长受限、先兆子痫和胎盘早剥相关，使APS成为一个严重的围产期问题。原发性形式可演变为狼疮样疾病或完全症状性红斑狼疮，两者通常先于急性形式的APS出现。在孕妇中，这种情况可能会带来相当大的诊断问题。这项工作的目的是介绍一名在妊娠和产褥期患有急性原发性抗磷脂综合征的患者，该患者随后被诊断为系统性红斑狼疮发作。这种进展很少见，尽管之前有几份报告，但仍需要广泛的解释和研究。
