Department of Communicable Diseases (Vaccinology) & Research Development, Medical Research Administration, Ministry of Health, Riyadh, Saudi Arabia.
East Mediterr Health J. 2011 Mar;17(3):191-5.
In 2001, the measles immunization schedule in Saudi Arabia was changed to 2 measles, mumps and rubella vaccine doses at 12 months and at 6 years. In this follow-up study we evaluated the seroresponse to the second measles dose before school entry. We recruited 138 children randomly from primary health care centres in Qassim; 124 children completed the study. Blood samples were collected before and 1 month after giving the second measles dose, before the age of 6 years. There was a statistically significant increase in the geometric mean titre of measles antibody, from 2205 m IU/mL before vaccination to 4723 mlU/mL after (P = 0.0001). The proportion of children with positive ELISA results increased fro++ 94.2% before vaccination to 99.2% after (P = 0.02), while the proportion with protective level (> or = 200 mlU/mL) increased from 97.1% before vaccination to 99.19% after (P = 0.21). The 2-dose measles immunization schedule can produce optimum protection at school entry if high vaccination coverage is guaranteed.
2001 年，沙特阿拉伯改变了麻疹免疫计划，将麻疹、腮腺炎和风疹疫苗的接种剂量从 12 个月和 6 岁改为 2 剂。在这项随访研究中，我们评估了入学前第二剂麻疹疫苗的血清反应。我们从盖西姆的初级保健中心随机招募了 138 名儿童；124 名儿童完成了这项研究。在 6 岁之前，在接种第二剂麻疹疫苗前和接种后 1 个月采集血样。接种后麻疹抗体的几何平均滴度从接种前的 2205 mIU/mL 显著增加到 4723 mIU/mL（P = 0.0001）。接种前 ELISA 结果阳性的儿童比例从 94.2%增加到接种后的 99.2%（P = 0.02），而保护性水平（>或= 200 mIU/mL）的比例从接种前的 97.1%增加到接种后的 99.19%（P = 0.21）。如果能保证高疫苗接种覆盖率，那么两剂麻疹免疫接种计划可以在入学时提供最佳保护。
