ABCC1 多态性 Arg723Gln（2168G> A）与中国人群肺癌易感性相关。

ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population.

Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China.

Clin Exp Pharmacol Physiol. 2011 Sep;38(9):632-7. doi: 10.1111/j.1440-1681.2011.05571.x.

Abstract

In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1-induced multidrug resistance. The aim of the present study was to further investigate the association of this polymorphism with lung cancer susceptibility and chemotherapy response in a Chinese population. 2. A total of 77 lung cancer patients (54 men, 23 women) and 71 cancer-free controls (49 men, 22 women) were enrolled in the study. Genomic DNA was extracted from peripheral blood and all samples were genotyped using polymerase chain reaction-restriction fragment length polymorphism. 3. Individuals carrying the 723Gln (A) allele have a 3.4-fold increased risk (adjusted odds ratio (OR) 3.42; 95% confidence interval (CI) 1.29-9.06; P = 0.013) of lung cancer compared with wild-type individuals. Further stratified analysis indicated that older individuals (> 50 years) carrying the 723Gln (A) allele have the highest susceptibility to lung cancer (adjusted OR 4.10; 95% CI 1.25-13.48; P = 0.020). However, no substantial association was found between the Arg723Gln (2168G > A) polymorphism and chemotherapy response in Chinese lung cancer patients. 4. In conclusion, the Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population, especially in older people.

摘要

在之前的一项体外研究中，我们发现 Arg723Gln（2168G > A）多态性显著诱导 ABCC1 引起的多药耐药。本研究的目的是进一步探讨该多态性与中国人群肺癌易感性和化疗反应的关系。
共纳入 77 例肺癌患者（54 名男性，23 名女性）和 71 名非癌症对照者（49 名男性，22 名女性）。从外周血中提取基因组 DNA，所有样本均采用聚合酶链反应-限制性片段长度多态性进行基因分型。
携带 723Gln（A）等位基因的个体患肺癌的风险增加了 3.4 倍（调整后的优势比（OR）3.42；95%置信区间（CI）1.29-9.06；P = 0.013）与野生型个体相比。进一步的分层分析表明，携带 723Gln（A）等位基因的年龄较大（>50 岁）的个体患肺癌的风险最高（调整后的 OR 4.10；95%CI 1.25-13.48；P = 0.020）。然而，在中国肺癌患者中，ABCC1 的 Arg723Gln（2168G > A）多态性与化疗反应之间没有显著关联。
总之，ABCC1 的 Arg723Gln（2168G > A）多态性似乎是中国人群肺癌的一个潜在易感性标志物，尤其是在老年人中。