Monreal M, Viñas L, Monreal L, Lavin S, Lafoz E, Angles A M
Unit of Experimental Thrombosis, Facultad de Veterinaria, Universidad Autónoma de Barcelona, España.
Haemostasis. 1990;20(4):204-7. doi: 10.1159/000216128.
In an animal model, the effect of a high dose of conventional heparin (2 IU/g s.c. twice a day) and a low-molecular-weight heparin (LMWH; Fragmin, 1 anti-Xa U/g once a day) was compared with that of placebo on the mineral bone mass in the femur of rats. After 33 days of treatment no differences were found in the weight of the femur. But heparin-treated rats exhibited a lower density (1,249 +/- 0.046 g/ml as compared with that in control rats (p = 0.00007) and also in LMWH-treated rats (p = 0.001). Similarly, statistically significant differences have been found in ash contents. They were higher in control rats than in heparin-treated rats (p = 0.0002), and also slightly higher than in LMWH-treated rats (p = 0.01). Our findings suggest that LMWH may have a lower osteopenic effect than that of conventional heparin.
在动物模型中，将高剂量常规肝素（2国际单位/克，皮下注射，每日两次）和低分子量肝素（LMWH；法安明，1抗Xa单位/克，每日一次）对大鼠股骨矿物质骨量的影响与安慰剂进行了比较。治疗33天后，股骨重量未发现差异。但肝素治疗的大鼠密度较低（与对照大鼠相比为1,249±0.046克/毫升，p = 0.00007），低分子量肝素治疗的大鼠也是如此（p = 0.001）。同样，在灰分含量上发现了统计学上的显著差异。对照大鼠的灰分含量高于肝素治疗的大鼠（p = 0.0002），也略高于低分子量肝素治疗的大鼠（p = 0.01）。我们的研究结果表明，低分子量肝素的骨质减少作用可能低于常规肝素。
