Allergy-Immunology Division, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.
Immunol Allergy Clin North Am. 2011 Aug;31(3):433-9. doi: 10.1016/j.iac.2011.05.009. Epub 2011 Jun 12.
The immune response to an allergen depends on an initial sensitization process, with future exposures triggering a 2-part allergic response including an early and late phase. The process by which an allergen is recognized has become clearer. Similarly, the roles of the preformed mediators responsible for many of the signs and symptoms of the early-phase response have been elucidated. Recent work also has shed some light on the cells and mediators involved in the late-phase reactions. This article discusses some of this recent work and reviews the basics behind of all of the stages of the allergic response.
过敏原的免疫反应取决于初始致敏过程，未来的接触会引发包括早期和晚期阶段的两部分过敏反应。过敏原识别的过程变得更加清晰。同样，负责许多早期反应迹象和症状的预先形成介质的作用也已经阐明。最近的研究也揭示了晚期反应中涉及的细胞和介质。本文讨论了其中的一些最新研究，并回顾了过敏反应所有阶段背后的基础知识。
