与胶质母细胞瘤复发和生存相关的治疗、性别和种族特异性 microRNA 标志物、靶基因和网络。
Therapy-, gender- and race-specific microRNA markers, target genes and networks related to glioblastoma recurrence and survival.
机构信息
Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA.
出版信息
Cancer Genomics Proteomics. 2011 Jul-Aug;8(4):173-83.
AIM
To identify and study targets of microRNA biomarkers of glioblastoma survival across events (death and recurrence) and phases (life expectancy or post-diagnostic) using functional and network analyses.
MATERIALS AND METHODS
microRNAs associated with glioblastoma survival within and across race, gender, recurrence, and therapy cohorts were identified using 253 individuals, 534 microRNAs, Cox survival model, cross-validation, discriminant analyses, and cross-study comparison.
RESULTS
All 45 microRNAs revealed as being associated with survival were confirmed in independent cancer studies and 25 in glioblastoma studies. Thirty-nine and six microRNAs (including hsa-miR-222) were associated with one and multiple glioblastoma survival indicators, respectively. Nineteen and 26 microRNAs exhibited cohort-dependent (including hsa-miR-10b with therapy and hsa-miR-486 with race) and independent associations with glioblastoma, respectively.
CONCLUSION
Sensory perception and G protein-coupled receptor processes were enriched among microRNA gene targets also associated with survival and network visualization highlighted their relations. These findings can help to improve prognostic tools and personalized treatments.
目的
使用功能和网络分析，确定并研究跨越事件（死亡和复发）和阶段（预期寿命或诊断后）的胶质母细胞瘤生存的 microRNA 生物标志物的靶点。
材料与方法
使用 253 名个体、534 个 microRNA、Cox 生存模型、交叉验证、判别分析和跨研究比较，鉴定与种族、性别、复发和治疗队列内及跨队列的胶质母细胞瘤生存相关的 microRNAs。
结果
所有与生存相关的 45 个 microRNAs均在独立的癌症研究中得到了证实，其中 25 个在胶质母细胞瘤研究中得到了证实。39 个和 6 个 microRNAs（包括 hsa-miR-222）分别与一个和多个胶质母细胞瘤生存指标相关。19 个和 26 个 microRNAs分别表现出与胶质母细胞瘤相关的队列依赖性（包括与治疗相关的 hsa-miR-10b 和与种族相关的 hsa-miR-486）和独立性。
结论
感觉感知和 G 蛋白偶联受体过程在与生存相关的 microRNA 基因靶点中富集，网络可视化突出了它们的关系。这些发现有助于改善预后工具和个性化治疗。
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