Sahlgrenska Academy, Department of Surgery, Sahlgrenska University Hospital, Östra, 41685 Gothenburg, Sweden.
Anticancer Res. 2011 Jun;31(6):2347-50.
Tumours of the right and left colon are suggested to be different entities with different prognosis. The aim was to explore differences related to the location of a colonic tumour.
A single-centre retrospective analysis of all patients treated for colon cancer during 1999-2008 (n=1558) was carried out. Assessed data included demography, pathology and survival by cancer location, with left colon also sub-divided into left and sigmoid colon.
Right colon carcinoma was associated with female gender, higher age and poor grade of differentiation; left colon carcinoma had characteristics of worse stages and requiring emergency surgery. Sigmoid tumours were of better grade and stage. Survival was related the staging, which varied with location. Right colon carcinoma conferred a worse overall survival (OS) (p<0.037) but not cancer-specific survival (CSS) or disease-free survival compared to the entire left colon, whilst sigmoid tumours conferred a better OS and CSS (p<0.001) when the left colon was sub-divided.
There are differences in demography and pathology related to the location of colon cancer. Sigmoid location carries the best prognosis.
右半结肠和左半结肠肿瘤被认为是具有不同预后的两种不同实体。本研究旨在探讨与结肠肿瘤位置相关的差异。
对 1999 年至 2008 年间在单中心接受结肠癌治疗的所有患者（n=1558）进行了回顾性分析。评估的数据包括根据肿瘤位置的人口统计学、病理学和生存情况，左半结肠进一步分为左半结肠和乙状结肠。
右半结肠癌与女性、高龄和低分化有关；左半结肠癌分期较差，需要急诊手术。乙状结肠肿瘤分化程度较好，分期也较好。生存与分期有关，与位置有关。与整个左半结肠相比，右半结肠癌的总生存期（OS）较差（p<0.037），但无病生存期（DFS）和癌症特异性生存期（CSS）无差异；当将左半结肠进一步分为左半结肠和乙状结肠时，乙状结肠肿瘤的 OS 和 CSS 较好（p<0.001）。
与结肠癌的位置相关的人口统计学和病理学存在差异。乙状结肠的位置预后最好。
