Hsu Christine, Saif Muhammad Wasif
Columbia University College of Physicians and Surgeons, New York, NY, USA.
JOP. 2011 Jul 8;12(4):330-3.
Pancreatic cancer is the fourth leading cause of cancer death in the United States. Risk factors for pancreatic cancer are smoking, family history, chronic pancreatitis, and diabetes. There is controversy with regards to the causal relationship between diabetes and pancreatic cancer because many patients with pancreatic cancer have new onset diabetes. Abstracts presented at the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting highlighted and supported the positive association between pancreatic cancer and diabetes. Abstract #4102 reports a two-fold risk of pancreatic cancer in diabetic patients. Abstract #4063 also presented at the 2011 ASCO Meeting shows that metformin prolongs survival and decreases risk of death in patients with pancreatic malignancy and diabetes.
胰腺癌是美国癌症死亡的第四大主要原因。胰腺癌的风险因素包括吸烟、家族病史、慢性胰腺炎和糖尿病。糖尿病与胰腺癌之间的因果关系存在争议，因为许多胰腺癌患者会新发糖尿病。在2011年美国临床肿瘤学会（ASCO）年会上发表的摘要强调并支持了胰腺癌与糖尿病之间的正相关关系。摘要#4102报告称糖尿病患者患胰腺癌的风险是正常人的两倍。同样在2011年ASCO会议上发表的摘要#4063表明，二甲双胍可延长胰腺恶性肿瘤合并糖尿病患者的生存期并降低死亡风险。
