Del Mistro A, Laverda A, Calabrese F, De Martino M, Calabri G, Cogo P, Cocchi P, D'Andrea E, De Rossi A, Giaquinto C
Istituto di Oncologia, Centro Interuniversitario per la Ricerca sul Cancro (CIRC), Università di Padova, Italy.
Am J Clin Pathol. 1990 Dec;94(6):722-8. doi: 10.1093/ajcp/94.6.722.
Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis.
尸检发现，两名分别在6个月和14个月大时死于获得性免疫缺陷综合征（AIDS）的儿童患有中枢神经系统非霍奇金淋巴瘤。未出现淋巴瘤的全身症状。在一例中通过免疫组织化学确定了肿瘤细胞的B细胞起源和克隆性，在另一例中通过免疫球蛋白基因重排的分子分析确定。此外，在后一例中，肿瘤细胞的特征是存在单个游离型EBV基因组。根据这些数据，单克隆B细胞增殖发生在EBV感染之后，因此提示EBV在淋巴瘤发生的早期阶段可能具有致病作用。
