Department of Respiratory Medicine, Sir Run Run Shaw Hospital , Zhejiang University School of Medicine, Hangzhou, People’s Republic of China.
Pharmacopsychiatry. 2011 Jul;44(5):183-8. doi: 10.1055/s-0031-1280814. Epub 2011 Jul 7.
Antipsychotics have been inconclusively implicated in susceptibility to venous thromboembolism (VTE).
The aim of this study was to investigate the association between antipsychotic drugs and VTE risk by a meta-analysis. PubMed and EmBASE databases were searched for publications through to 10 October 2010. Statistical analysis was performed using Revman 4.2 and Stata 10.0 software.
7 case-control studies involving 31 095 cases and 143 472 controls were analyzed. The results indicate that antipsychotic exposure confers a 139 % increased risk of VTE (odds ratio [OR] = 2.39, 95 % confidence interval [CI]:1.71–3.35). Pooled estimates by drug type showed that use of low-potency antipsychotics (OR = 2.91, 95 % CI 1.80–4.71) is the most important risk factor for VTE, followed by atypical (OR = 2.20, 95 % CI 1.22–3.96), conventional (OR = 1.72, 95 % CI 1.31–2.24) and high-potency drugs (OR = 1.58, 95 % CI 1.50–1.67).
This meta-analysis suggests that antipsychotics are a risk factor for VTE. Additional studies in large cohorts are required to validate our findings. Future analyses should study potential eff ect modifications by different doses and durations of antipsychotic exposure in different populations.
抗精神病药与静脉血栓栓塞症（VTE）的易感性之间的关系尚未确定。
本研究旨在通过荟萃分析研究抗精神病药物与 VTE 风险之间的关系。通过检索 PubMed 和 EmBASE 数据库，截至 2010 年 10 月 10 日，查找相关文献。使用 Revman 4.2 和 Stata 10.0 软件进行统计分析。
分析了 7 项病例对照研究，共涉及 31095 例病例和 143472 例对照。结果表明，抗精神病药物暴露使 VTE 的风险增加了 139%（比值比[OR] = 2.39，95%置信区间[CI]：1.71–3.35）。按药物类型进行的汇总估计表明，使用低效能抗精神病药物（OR = 2.91，95%CI 1.80–4.71）是 VTE 的最重要危险因素，其次是新型（OR = 2.20，95%CI 1.22–3.96）、传统（OR = 1.72，95%CI 1.31–2.24）和高效能药物（OR = 1.58，95%CI 1.50–1.67）。
本荟萃分析表明，抗精神病药物是 VTE 的一个危险因素。需要在大型队列中进行更多的研究来验证我们的发现。未来的分析应该研究不同人群中不同剂量和持续时间的抗精神病药物暴露对潜在效应的修饰作用。
