Pharmacopsychiatry. 2013 Jan;46(1):36-7. doi: 10.1055/s-0032-1316347. Epub 2012 Jul 20.
In a meta-analysis of case-control studies, Zhang et al. (2011) found an increased risk of venous thromboembolic events (VTE) in patients exposed to antipsychotics (OR=2.39 [1.71-3.35]). Our updated meta-analysis including the 2 available cohort studies, recognized as a more relevant type of observational study, showed a weaker, but still strong association (OR=1.84 [1.39; 2.44]). In view of the lack of data on the confirmed risk factors for VTE in existing studies, prospective studies including adjustment for these risk factors are warranted to confirm this association and to assess the benefit/risk ratio of antipsychotics in high-risk patients.
在一项病例对照研究的荟萃分析中，Zhang 等人（2011 年）发现暴露于抗精神病药物的患者发生静脉血栓栓塞事件（VTE）的风险增加（OR=2.39 [1.71-3.35]）。我们的更新荟萃分析包括 2 项可用的队列研究，被认为是一种更相关的观察性研究类型，显示出较弱但仍然很强的关联（OR=1.84 [1.39; 2.44]）。鉴于现有研究中缺乏 VTE 确诊危险因素的数据，需要进行包括这些危险因素调整的前瞻性研究来证实这种关联，并评估高危患者使用抗精神病药物的获益/风险比。
