Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, California, USA.
Head Neck. 2012 Jun;34(6):763-70. doi: 10.1002/hed.21805. Epub 2011 Jul 7.
This study was carried out to report our experience using intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for tumors involving the base of skull.
In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45-70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment.
The 2-year local-regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial-lateral (ML), superior-inferior (SI), and anterior-posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively.
The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated.
本研究旨在报告我们使用调强放疗（IMRT）联合每日图像引导放疗（IGRT）治疗颅底肿瘤的经验。
共有 100 例患者接受了中位剂量为 64Gy（范围为 45-70Gy）的调强放疗。作为患者配准的 IGRT 登记方案的一部分，每天进行螺旋式兆伏 CT（MVCT）扫描。
2 年局部区域控制率为 91%。共获得 3295 次每日 MVCT 扫描。为了补偿分次间运动，平均内-外侧（ML）、上-下（SI）和前-后（AP）方向的位移分别为 1.18±1.75mm、1.81±1.34mm 和 1.33±1.19mm。ML、SI 和 AP 方向的预治疗位移>3mm 的发生率分别为 10%、26%和 18%。
每日 IGRT 作为颅底 IMRT 的补充是可行和有效的。
