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CD4(+) 效应和中央记忆 T 细胞的起源。

Origins of CD4(+) effector and central memory T cells.

机构信息

Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.

出版信息

Nat Immunol. 2011 Jun;12(6):467-71. doi: 10.1038/ni.2038.

DOI:10.1038/ni.2038
PMID:21739668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4212218/
Abstract

Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T(FH) cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.

摘要

定谱系效应 CD4(+) T 细胞在初级反应高峰时产生，随后是中央和效应记忆细胞的异质群体。在这里，我们回顾了证据表明 T 辅助细胞 1（T(H)1）效应细胞在初级反应的收缩阶段存活并成为效应记忆细胞。我们讨论了这个想法对 T(H)2 细胞、T(H)17 辅助 T 细胞、滤泡辅助 T 细胞（T(FH)细胞）和诱导性调节 T 细胞谱系的适用性。我们还讨论了中央记忆细胞是如何形成的，重点介绍了 B 细胞在这个过程中的作用。

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本文引用的文献

[1]
Fate mapping of IL-17-producing T cells in inflammatory responses.

Nat Immunol. 2011-1-30

[2]
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.

Immunity. 2011-1-6

[3]
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.

Nat Immunol. 2010-12-12

[4]
Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.

PLoS Pathog. 2010-11-24

[5]
Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.

J Immunol. 2010-11-3

[6]
Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.

J Immunol. 2010-7-9

[7]
Differentiation of effector CD4 T cell populations (*).

Annu Rev Immunol. 2010

[8]
Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice.

J Immunol. 2010-2-26

[9]
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.

Nat Immunol. 2009-11-22

[10]
A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy.

Immunity. 2009-11-20

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