Charles-Chess Nana Appiah Essel, Kurup Samarchith P
Department of Cellular Biology, University of Georgia, Athens, GA, United States.
Center for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, United States.
J Immunol. 2025 Aug 1;214(8):1872-1880. doi: 10.1093/jimmun/vkaf067.
Regulatory T cells (Tregs) can persist as memory cells (mTregs) in both infectious and non-infectious settings. However, their functional behavior, phenotypic stability, and suppressive properties upon antigen re-exposure remain poorly understood. Emerging evidence suggests that mTregs exhibit enhanced proliferation and suppressive capacity upon re-encountering the same antigen, a feature that may be critical in recurrent infections such as malaria. In malaria, Tregs are known to modulate immune responses and influence acute disease outcomes, suggesting that mTreg recall may play a significant role in long-term immunity. This review explores the biology of Treg memory, with a focus on malaria, and examines the immunological implications of maintaining a suppressive mTreg population in malaria immunity.
调节性T细胞（Tregs）在感染性和非感染性环境中均可作为记忆细胞（mTregs）持续存在。然而，它们在再次接触抗原后的功能行为、表型稳定性和抑制特性仍知之甚少。新出现的证据表明，mTregs在再次遇到相同抗原时表现出增强的增殖和抑制能力，这一特征在疟疾等复发性感染中可能至关重要。在疟疾中，已知Tregs可调节免疫反应并影响急性疾病结局，这表明mTreg的记忆反应可能在长期免疫中发挥重要作用。本综述探讨了Treg记忆的生物学特性，重点关注疟疾，并研究了在疟疾免疫中维持具有抑制作用的mTreg群体的免疫学意义。
