分析确诊的萘呋胺（萘基吡咯烷酮）消遣性使用导致的拟交感神经毒性。
Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone).
机构信息
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
出版信息
Clin Toxicol (Phila). 2011 Aug;49(7):691-3. doi: 10.3109/15563650.2011.592838. Epub 2011 Jul 8.
CONTEXT
Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone.
CASE
We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. Naphyrone was detected in the patient's plasma by gas chromatography with mass spectrometry at concentrations of 0.03 and 0.02 mg/L, 40 and 60 h after drug intake, respectively.
DISCUSSION
Based on the present case report and user web-reports, as well as on the chemical structure and pharmacological characteristics, naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity.
背景
萘呋胺（萘基吡咯烷酮）是一种金刚烷酮衍生物和与麦角酸二乙胺有关的娱乐性药物。
案例
我们报告了一名 31 岁的男性，他摄入了一剂萘呋胺（100 毫克），导致急性拟交感神经毒性，表现为烦躁不安、失眠、焦虑和幻觉，持续了 2 天。在摄入药物后 40 和 60 小时，患者的血浆中分别通过气相色谱-质谱法检测到浓度为 0.03 和 0.02 毫克/升的萘呋胺。
讨论
基于本病例报告和用户网络报告，以及基于化学结构和药理学特征，萘呋胺产生类似兴奋剂的精神活性作用和拟交感神经毒性。
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