Department of Medicine, Ben-Gurion University Soroka University Medical Center, Beer-Sheva, Israel.
Int J Tuberc Lung Dis. 2011 Aug;15(8):1050-5. doi: 10.5588/ijtld.10.0344.
Not all health care workers (HCWs) are at the same risk for tuberculin skin test (TST) conversion, indicating latent tuberculosis (TB) infection.
To identify risk factors for TST conversion among HCWs.
A retrospective cohort study conducted at a tertiary university medical centre included every HCW who had had a negative two-step TST at work entry and at least one consecutive TST in the period 2005-2009 (mean follow-up period 55 months). Binomic logistic regression analysis was used to identify risk factors for TST conversion. Potential risk factors such as age, health care profession, patient exposure profile, workplace division and history of bacille Calmette-Guérin vaccination were entered in the model.
A total of 450 subjects met the inclusion criteria, of whom 93 had TST conversion. The highest annual rates of TST conversion occurred in workers who worked as housekeeping staff (6.9%). Older age, a work environment with high patient turnover and employment in maintenance departments were significant risk factors (adjusted odds ratios 2.05, 5.2 and 8.4 respectively).
Housekeeping staff, older age workers and health care professionals working in an environment of high patient turnover are at increased risk for latent TB infection.
并非所有医护人员（HCWs）都面临结核菌素皮肤试验（TST）转化的相同风险，这表明存在潜伏性结核（TB）感染。
确定 HCWs 中 TST 转化的危险因素。
在一家三级大学医学中心进行了一项回顾性队列研究，纳入了每位在工作入职时 TST 双步检测呈阴性且在 2005-2009 年期间至少有一次连续 TST 的 HCW（平均随访期为 55 个月）。二项逻辑回归分析用于确定 TST 转化的危险因素。模型中纳入了年龄、医疗保健职业、患者暴露情况、工作场所分工和卡介苗接种史等潜在危险因素。
共有 450 名符合纳入标准的受试者，其中 93 名 TST 转化。TST 转化的年发生率最高的是从事家政工作的工作人员（6.9%）。年龄较大、患者周转率高的工作环境以及在维修部门工作是显著的危险因素（调整后的优势比分别为 2.05、5.2 和 8.4）。
家政工作人员、年龄较大的工作人员以及在高患者周转率环境中工作的医疗保健专业人员感染潜伏性 TB 的风险增加。
