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立体定向抽吸和溶栓治疗自发性小脑内出血。

Stereotactic aspiration and thrombolysis of spontaneous intracerebellar hemorrhage.

机构信息

Precision Engineering Centre of Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.

出版信息

Chin Med J (Engl). 2011 Jun;124(11):1610-5.

Abstract

BACKGROUND

Spontaneous intracerebellar hemorrhage (SCH) accounts for 10% of intracerebral hemorrhages. Up to now stereotactic aspiration and thrombolysis of SCH was less reported. The aim of this study was to assess the effect and feasibility of the method, and to refine the clinical protocol.

METHODS

Eighteen patients with SCH were treated by stereotactic aspiration and thrombolysis and reviewed in this report. The 3-mm axial stereotactic computed tomography slices throughout the hematoma were obtained. Those images were then transferred to the workstation. The trajectory of catheter was designed to go through the main axis of the hematoma. Under local anesthesia a catheter was directed stereotactically into the hematoma through a burr hole. Hematoma thrombolysis and clot drainage was followed by instillation of urokinase (10,000 U) every 12 hours. The catheter was removed when the majority of hematoma was evacuated.

RESULTS

Initial SCH volume was reduced by an average of 86% and the average final hematoma volume was 2.8 ml. At 3-month follow-up, 13 patients (72%) had achieved good recovery. At 6-month follow-up, 12 patients (67%) had achieved good recovery.

CONCLUSION

Stereotactic aspiration and thrombolysis of SCH was a simple, feasible and effective method to treat moderate and some benign SCH that less respond to medical treatment.

摘要

背景

自发性小脑血肿(SCH)占脑出血的 10%。到目前为止,SCH 的定向吸引和溶栓治疗报道较少。本研究旨在评估该方法的效果和可行性,并完善临床方案。

方法

本报告回顾性分析了 18 例行定向吸引和溶栓治疗的 SCH 患者。获得整个血肿的 3mm 轴向 CT 切片。将这些图像传输到工作站。设计导管的轨迹使其穿过血肿的主轴。在局部麻醉下,通过颅骨钻孔将导管定向进入血肿。每 12 小时注入尿激酶(10000U)进行血肿溶栓和血块引流。当血肿大部分排空时,将导管取出。

结果

初始 SCH 体积平均减少 86%,平均最终血肿体积为 2.8ml。3 个月随访时,13 例(72%)患者恢复良好。6 个月随访时,12 例(67%)患者恢复良好。

结论

定向吸引和溶栓治疗 SCH 是一种治疗对药物治疗反应不佳的中等量和部分良性 SCH 的简单、可行、有效的方法。

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