视黄醇结合蛋白 4与妊娠胰岛素抵抗无关。
Retinol-binding protein 4 is not associated with insulin resistance in pregnancy.
机构信息
Endocrine, Hormone and Metabolism Research Unit, and Endocrinology and Metabolism Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Patumwan, Bangkok, Thailand.
出版信息
Metabolism. 2012 Jan;61(1):65-9. doi: 10.1016/j.metabol.2011.05.019. Epub 2011 Jul 7.
Retinol-binding protein 4 (RBP4) is an adipokine proposed to be specifically associated with insulin resistance (IR). We examined whether serum levels of RBP4 were associated with IR in pregnancy. One hundred seventy-two women with gestational diabetes mellitus (GDM) and 361 pregnant Thai women who did not have GDM but had a positive 50-g glucose challenge test result (plasma glucose level was ≥7.2 mmol/L after 1 hour) were enrolled. We measured fasting serum levels of RBP4 and assessed IR at a 100-g oral glucose tolerance test. We found a higher degree of IR in the GDM group compared with the non-GDM group, but serum RBP4 levels between the 2 groups were not different. Retinol-binding protein 4 levels were associated with serum triglyceride levels but were not associated with the degree of IR assessed by homeostasis model assessment or quantitative insulin sensitivity check index. Our results suggest that serum RBP4 levels in pregnancy are not associated with IR.
视黄醇结合蛋白 4（RBP4）是一种脂肪因子，被认为与胰岛素抵抗（IR）密切相关。本研究旨在探讨妊娠妇女血清 RBP4 水平与 IR 是否相关。共纳入 172 例妊娠期糖尿病（GDM）患者和 361 例糖耐量正常但 50g 葡萄糖筛查试验阳性（1 小时血糖≥7.2mmol/L）的泰国孕妇。检测所有研究对象空腹血清 RBP4 水平，并在口服 100g 葡萄糖耐量试验时评估 IR。结果显示，GDM 组的 IR 程度较非 GDM 组更为严重，但两组间血清 RBP4 水平并无差异。RBP4 水平与血清三酰甘油水平相关，但与稳态模型评估的 IR 程度或定量胰岛素敏感性检测指数无关。综上，本研究结果提示妊娠妇女血清 RBP4 水平与 IR 无关。
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