William R. Pritchard Veterinary Medical Teaching Hospital, University of California Davis, CA 95616, USA.
Vet J. 2012 Jun;192(3):511-3. doi: 10.1016/j.tvjl.2011.05.026. Epub 2011 Jul 7.
Equine proliferative enteropathy caused by Lawsonia intracellularis is an emerging disease with as yet unaddressed preventative measures. The hypothesis of this study was that vaccination will prevent clinical and sub-clinical disease. Weanling Thoroughbreds (n=202) from Central Kentucky were randomly assigned into two groups (vaccinated and non-vaccinated). Vaccinated foals received 30 mL of an avirulent, live L. intracellularis vaccine intra-rectally twice, 30 days apart. Foals were monitored for clinical disease, total solids and average weight gain until yearling age. There was an overall decreased disease incidence on the farms involved in the study that did not differ significantly between the groups. This decreased disease prevalence in the study population may be associated with the ongoing vaccine trial on these farms, as disease prevalence in Central Kentucky did not change in 2009 compared to 2008.
由细胞内罗松菌引起的马增生性肠病是一种新出现的疾病，目前尚无预防措施。本研究的假设是接种疫苗将预防临床和亚临床疾病。我们从肯塔基州中部随机选择 202 匹断奶纯种马（接种疫苗和未接种疫苗）分为两组。接种疫苗的小马通过直肠内两次接受 30 毫升无毒、活的 L. intracellularis 疫苗，间隔 30 天。监测小马的临床疾病、总固体物和平均体重增加，直到一岁。在参与研究的农场中，总体疾病发病率下降，但两组之间没有显著差异。研究人群中疾病流行率的降低可能与这些农场正在进行的疫苗试验有关，因为与 2008 年相比，2009 年肯塔基州中部的疾病流行率没有变化。
