Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, Adelaide, SA, Australia.
Lancet Oncol. 2011 Dec;12(13):1249-57. doi: 10.1016/S1470-2045(11)70040-7. Epub 2011 Jul 6.
More and more elderly people with cancer are treated in oncology clinics worldwide every year, many of whom have comorbid disorders treated with one or more drugs. Moreover, these patients might also take self-prescribed over-the-counter drugs or complementary and alternative medicines, which they might not tell their doctor about. Initiation of chemotherapy with one or more cytotoxic or targeted agents and drugs for treatment of cancer symptoms or toxic effects related to treatment can result in polypharmacy. We examine the clinical implications of polypharmacy. Challenges for the medical teams who treat elderly patients with cancer include identification of what drugs are actually being taken by the patient, avoidance or management of any adverse effects or drug interactions, and reassessing the patient's overall treatment. We address these issues and propose practical recommendations for management of treatment for elderly patients with cancer.
每年，全球有越来越多的老年癌症患者在肿瘤诊所接受治疗，其中许多人患有合并症，需要用一种或多种药物进行治疗。此外，这些患者还可能自行服用非处方药或补充和替代药物，但他们可能不会告诉医生。开始使用一种或多种细胞毒性药物或靶向药物以及治疗癌症症状或与治疗相关的毒性作用的药物可能会导致多种药物并用。我们检查了多种药物并用的临床意义。治疗老年癌症患者的医疗团队面临的挑战包括确定患者实际服用的药物、避免或处理任何不良反应或药物相互作用，以及重新评估患者的整体治疗。我们解决了这些问题，并为老年癌症患者的治疗提出了实用的管理建议。
