Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, Punjab, India.
Eur J Pharmacol. 2011 Sep 30;667(1-3):215-21. doi: 10.1016/j.ejphar.2011.06.017. Epub 2011 Jul 2.
The present study was designed to investigate the potential of telmisartan, an angiotensin AT(1) receptor, in chronic constriction injury-induced neuropathic pain in rats. Four loose ligatures were placed around the sciatic nerve to induce chronic constriction injury and neuropathic pain. Acetone drop, pin-prick, hot plate and paint brush tests were performed to assess cold allodynia; mechanical and heat hyperalgesia; and dynamic mechanical allodynia, respectively along with assessment of spontaneous pain and postural index in terms of foot deformity. The levels of TNF-α were measured in the sciatic nerve as an index of inflammation. Chronic constriction injury was associated with development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; and spontaneous pain and foot deformity along with rise in the levels of TNF-α. Telmisartan (1, 2, 5 mg/kg, p.o.) was administered for 14 days in chronic constriction injury subjected rats. Administration of telmisartan (2, 5 mg/kg) significantly attenuated chronic constriction injury-induced pain related behavior, foot deformity and rise in TNF-α level. It may be concluded that telmisartan has a potential in attenuating neuropathic pain behavior in chronic constriction injury model which may possibly be attributed to its anti-inflammatory properties.
本研究旨在探讨替米沙坦（一种血管紧张素 AT1 受体拮抗剂）对大鼠慢性缩窄性损伤诱导的神经性疼痛的潜在作用。通过在坐骨神经周围放置四个松动的结扎线来诱导慢性缩窄性损伤和神经性疼痛。通过使用丙酮滴注、针刺痛、热板和油漆刷测试来评估冷感觉异常；机械和热痛觉过敏；以及动态机械感觉异常，同时评估自发性疼痛和足部畸形的姿势指数。通过测量坐骨神经中的 TNF-α 水平来评估炎症程度。慢性缩窄性损伤与冷感觉异常、机械和热痛觉过敏、动态机械感觉异常、自发性疼痛和足部畸形的发展以及 TNF-α 水平的升高有关。替米沙坦（1、2、5mg/kg，口服）在慢性缩窄性损伤大鼠中连续给药 14 天。替米沙坦（2、5mg/kg）的给药显著减轻了慢性缩窄性损伤引起的与疼痛相关的行为、足部畸形和 TNF-α 水平的升高。可以得出结论，替米沙坦具有减轻慢性缩窄性损伤模型中神经性疼痛行为的潜力，这可能与其抗炎特性有关。
