Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kujirai, Kawagoe-shi, Saitama, Japan.
Brain Res Bull. 2011 Aug 10;86(1-2):1-12. doi: 10.1016/j.brainresbull.2011.06.006. Epub 2011 Jul 1.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease manifested by cognitive and memory deterioration, culminating in a spectrum of neuropsychiatric disturbances and the impairment of daily activities. AD is a multifactorial disease with a range of contributing factors which includes genes and diet. The magnitude of AD is reflected in the loss of individuality of the affected person and in the terminal course through which the disease develops. In this review, we aim to provide a background on AD and the contribution of cholesterol in the etiology of Alzheimer's. Cholesterol seems to be intimately linked with the generation of amyloid plaques, which is central to the pathogenesis of AD. Although there are conflicting reports on the role of cholesterol in AD, majority of the studies point out the positive association of cholesterol with AD.
阿尔茨海默病（AD）是最常见的神经退行性疾病，表现为认知和记忆功能恶化，最终导致一系列神经精神障碍和日常活动能力受损。AD 是一种多因素疾病，有多种致病因素，包括基因和饮食。AD 的严重程度反映在受影响者个性的丧失和疾病发展的终末过程中。在这篇综述中，我们旨在提供 AD 的背景信息以及胆固醇在阿尔茨海默病发病机制中的作用。胆固醇似乎与淀粉样斑块的产生密切相关，而淀粉样斑块是 AD 发病机制的核心。尽管关于胆固醇在 AD 中的作用存在相互矛盾的报告，但大多数研究都指出胆固醇与 AD 呈正相关。
