PhD Fellowship Research Foundation of Flanders (FWO Aspirant), Brussels, Belgium.
Osteoarthritis Cartilage. 2011 Sep;19(9):1123-31. doi: 10.1016/j.joca.2011.06.009. Epub 2011 Jun 26.
To monitor ankle cartilage 3D volume changes after in vivo exercise and during recovery.
Based on 3D MRI, 3D volumes of talar and tibial cartilage were calculated before and after 30 bilateral knee bends in 12 healthy volunteers. 3D volumes were calculated at five time points (one pre- and four post-scans) determining deformation and recovery for both cartilage plates of interest. Post-scans ran immediately after the exercise and were repeated according to a 15 min interval. 3D volumes were subjected to repeated measures GLM. Additionally, relative surface area use during deformation was compared between plates using a Wilcoxon Signed Ranks test and its correlation with deformation was investigated using Spearman's rho.
Mean 3D volume change percentages for talar cartilage after the exercise were: -10.41%, -8.18%, -5.61% and -3.90%. For tibial cartilage mean changes were: -5.97%, -5.75%, +0.89% and +1.51%. For talar cartilage changes were significant, except following 30 min post-exercise. For tibial cartilage no changes were significant. At all time points, no significant differences in relative volume changes between both cartilage plates existed. Although no significant differences in relative surface area use between plates were revealed, a moderate to strong correlation with deformation existed.
Ankle cartilage endures substantial deformation after in vivo loading that was restored within 30 min for the talus. Overall cartilage contact area involvement might be associated with cartilage quality maintenance in the upper ankle. Talar cartilage is suggested to play a critical role in intra-articular shock attenuation when compared to tibial cartilage.
监测活体运动后及恢复过程中踝关节软骨的 3D 体积变化。
基于 3D MRI，在 12 名健康志愿者中，在 30 次双侧膝关节弯曲后，计算出距骨和胫骨软骨的 3D 体积。在五个时间点（一次预扫描和四次后扫描）计算 3D 体积，以确定感兴趣的两个软骨板的变形和恢复。后扫描在运动后立即进行，并根据 15 分钟的间隔重复进行。对 3D 体积进行重复测量 GLM。此外，使用 Wilcoxon 符号秩检验比较两个板在变形过程中的相对表面积利用率，并使用 Spearman rho 研究其与变形的相关性。
距骨软骨在运动后的 3D 体积变化百分比平均值分别为：-10.41%、-8.18%、-5.61%和-3.90%。胫骨软骨的平均变化分别为：-5.97%、-5.75%、+0.89%和+1.51%。除了在运动后 30 分钟外，距骨软骨的变化均具有统计学意义。胫骨软骨的变化无统计学意义。在所有时间点，两个软骨板之间的相对体积变化无显著差异。虽然两个板之间的相对表面积利用率无显著差异，但与变形存在中度至强相关性。
踝关节软骨在活体负荷后会发生明显的变形，在 30 分钟内恢复。整个软骨接触面积的参与可能与上踝关节软骨质量的维持有关。与胫骨软骨相比，距骨软骨在关节内冲击衰减中发挥着关键作用。
