Imaging Sciences Department, Imperial College Hammersmith Hospital, London, UK.
Ultrasound Med Biol. 2011 Sep;37(9):1509-17. doi: 10.1016/j.ultrasmedbio.2011.05.020. Epub 2011 Jul 8.
Previous work by the authors has established that increasing the temperature of the suspending liquid from 20°C to body temperature has a significant impact on the bulk acoustic properties and stability of an ultrasound contrast agent suspension (SonoVue, Bracco Suisse SA, Manno, Lugano, Switzerland). In this paper the influence of temperature on the nonlinear behavior of microbubbles is investigated, because this is one of the most important parameters in the context of diagnostic imaging. High-speed imaging showed that raising the temperature significantly influences the dynamic behavior of individual microbubbles. At body temperature, microbubbles exhibit greater radial excursion and oscillate less spherically, with a greater incidence of jetting and gas expulsion, and therefore collapse, than they do at room temperature. Bulk acoustics revealed an associated increase in the harmonic content of the scattered signals. These findings emphasize the importance of conducting laboratory studies at body temperature if the results are to be interpreted for in vivo applications.
作者之前的工作已经表明，将悬浮液的温度从 20°C 升高到体温对超声造影剂悬浮液（SonoVue，Bracco Suisse SA，Manno，Lugano，瑞士）的体声波特性和稳定性有重大影响。本文研究了温度对微泡非线性行为的影响，因为这是诊断成像中最重要的参数之一。高速成像表明，温度升高会显著影响单个微泡的动力学行为。在体温下，微泡表现出更大的径向位移，并且在球形振荡方面的表现更差，射流和气体排出的发生率更高，因此比在室温下更容易发生破裂。体声波揭示了散射信号的谐波含量的相应增加。这些发现强调了如果要对体内应用的结果进行解释，则必须在体温下进行实验室研究。
