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美国骨科基金会(OFA)如何应对遗传性疾病:以髋关节和肘关节炎为例。

How the Orthopedic Foundation for Animals (OFA) is tackling inherited disorders in the USA: using hip and elbow dysplasia as examples.

机构信息

Orthopedic Foundation for Animals, Columbia, MO 65201-3806, USA.

出版信息

Vet J. 2011 Aug;189(2):197-202. doi: 10.1016/j.tvjl.2011.06.019. Epub 2011 Jul 8.

DOI:10.1016/j.tvjl.2011.06.019
PMID:21741865
Abstract

The Orthopedic Foundation for Animals (OFA) maintains an on-line health pedigree database for inherited disorders of animals. With the American Kennel Club Canine Health Foundation, the OFA maintains the Canine Health Information Center (CHIC) for parent breed clubs to identify breed-specific required health tests. Analysis of the results of OFA evaluations in the hip and elbow registries show that selection based on phenotype improves conformation. Disorders with complex inheritance respond best to selection based on depth (ancestors) and breadth (siblings) of pedigree health test results. This information can be derived from vertical pedigrees generated on the OFA website.

摘要

动物骨科基金会(OFA)维护一个在线健康血统数据库,用于记录动物的遗传疾病。与美国养犬俱乐部犬类健康基金会合作,OFA 维护犬类健康信息中心(CHIC),为父系品种俱乐部提供识别特定品种所需的健康测试。对髋关节和肘关节登记处 OFA 评估结果的分析表明,基于表型的选择可以改善结构。具有复杂遗传的疾病对基于谱系健康测试结果的深度(祖先)和广度(兄弟姐妹)的选择反应最好。这些信息可以从 OFA 网站上生成的垂直血统中得出。

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